Gut Protease Signals
Team 1
Research Programs
The general objective of the “Gut Protease Signals” team is to understand the mechanisms of diseases associated with dysfunctions of the intestinal epithelium: chronic inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), colorectal cancer, and infections. The research team has expertise in intestinal mucosa biology, particularly in its barrier functions, secretory functions, absorption, regeneration, the neuronal control of secretion and motility, intestinal nociception and visceral pain, as well as the interaction between host/microbiota/pathogens.
The role of mucosal proteolytic balance in intestinal physiology and pathologies is a key focus of study. Certain proteolytic activities have been shown to be deregulated in various pathophysiological contexts, and these proteases are now being thoroughly investigated to clarify their roles in pathogenesis. The involvement of protease-activated receptors (PARs) in digestive pathologies is an historical and major line of investigation for the team.
Additionally, our team is interested in how gender and age may influence pathologies arising from alterations in the intestinal crypt. Pain associated with the intestinal organ is also a major focus of the team, which investigates mechanisms of visceral hypersensitivity, in order to propose new therapeutic options for the treatment of visceral pain and discomfort. A focus on the relationship between epithelial, immune and microbial mediators in mediating nociceptive signals is proposed, in an attempt to understand the complexity of peripheral signals involved in acute and chronic pain signaling in the gut.
Strong partnerships have been established with pharmaceutical industry to develop therapeutic molecules targeting mediators identified for their pathogenic role in intestinal pathologies.
People
Tools and models
- Human and Murine Organoid Models: Organoids allow for the in vitro, three-dimensional recreation of an intestinal epithelial monolayer, encompassing the full diversity of intestinal epithelial cells while preserving tissue architecture. These in vitro models are powerful tools for fundamental research in intestinal physiology and pathophysiology, as well as for therapeutic development. We run organoid models from colon and small intestine, from healthy controls or patient’s tissues, in 3-dimensions and in transwells (interfaced organoid cultures with microbiota and immune cells).
- Human and murine intestinal epithelial cell lines
- In vitro and in vivo evaluation of intestinal epithelial barrier function
- Animal models of chronic inflammatory bowel disease (DSS, TNBS, oxazolone)
- Animal models of Irritable Bowel Syndrome (patient’s tissues-derived, stress, post-infectious)
- Bacterial infection models (Salmonella, Pseudomonas)
- Biofilm culture models and gut microbiota studies
- Animal models of visceral hypersensitivity, visceral pain measures
- Animal models of colorectal cancer
- Postoperative ileus models
- Protease biochemistry: production, measurement of proteolytic activity, activity-based probe profiling
- Protease-Activated Receptors (PARs): knockout mice, transgenic cell lines, CRISPR-Cas9-modified cell lines, pharmacological antagonists
- Transgenic mice overexpressing proteases (Elastase, Trypsin-3), and mice deficient for some protease expression.
Publications
Article type:
Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury. Nina Colitti, Edwige Rice, ..., Nathalie Vergnolle, et al., Advanced Science 2026. DOI: 10.1002/advs.202503362
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review. Andreas Papapetropoulos, Stavros Topouzis, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2026. DOI: 10.1111/bph.70376
β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., Journal of Biomedical Science 2026. DOI: 10.1186/s12929-026-01249-8
The role of dietary patterns on epigenetic and inflammatory aging based on the INSPIRE-T study. Natasha Grande de França, Yves Rolland, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Céline Deraison, Chrystelle Bonnart, et al., Communications Medicine 2026. DOI: 10.1038/s43856-026-01643-1
High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation. Guillaume Le Cosquer, Melissa Pannier, ..., Laura Guiraud, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gut Microbes 2026. DOI: 10.1080/19490976.2026.2687903
Updated *BJP* guidelines for transparent and rigorous natural product research. Xin Wang, Tayyiba Azam, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2026. DOI: 10.1111/bph.70420
Response to: Justifying and reporting the use of severe stress in experiments that use animals. Charles Whalley, Marie Anne Engh, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2026. DOI: 10.1111/bph.70411
Bidirectional associations between biological aging, cardiovascular health, and cardiovascular risk: findings from the INSPIRE-T lifespan cohort. Mathilde Strumia, Vanina Bongard, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Céline Deraison, Chrystelle Bonnart, et al., GeroScience 2026. DOI: 10.1007/s11357-026-02251-6
Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity. Laure Rouch, Philipe de Souto Barreto, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Céline Deraison, Chrystelle Bonnart, et al., JAMA Network Open 2026. DOI: 10.1001/jamanetworkopen.2026.24102
Additional file 4 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163851
Additional file 1 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163842.v1
Additional file 4 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163851.v1
Additional file 2 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163845.v1
Additional file 5 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163854.v1
Additional file 3 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163848
β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.c.8458124
Additional file 5 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163854
β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.c.8458124.v1
Additional file 1 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163842
Additional file 3 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163848.v1
Additional file 2 of β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset. Francesca Terrin, Sofia Faggin, et al., 2026. DOI: 10.6084/m9.figshare.32163845
Guidance on the planning and reporting of experimental design and analysis. Michael J. Curtis, S P H Alexander, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2025. DOI: 10.1111/bph.17441
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review. Stavros Topouzis, Andreas Papapetropoulos, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2025. DOI: 10.1111/bph.17458
Pharmacology of Intestinal Inflammation and Repair. Céline Deraison, Nathalie Vergnolle, Annual Review of Pharmacology and Toxicology 2025. DOI: 10.1146/annurev-pharmtox-051921-084536
Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3. Mélissa David, Anaïs Faihy, ..., Anissa Edir, ..., Nathalie Vergnolle, ..., Céline Deraison, British Journal of Pharmacology 2025. DOI: 10.1111/bph.70100
Pathogenicity of commensal gut biofilm in prefrail aging. Guillaume Le Cosquer, Melissa Pannier, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, et al., npj Biofilms and Microbiomes 2025. DOI: 10.1038/s41522-025-00716-8
Oral indomethacin modifies small intestine biofilms and host-microbe interaction mediators. Arezoo Haghighi, András S. Tóth, ..., Jean‐Paul Motta, Nathalie Vergnolle, et al., Life Sciences 2025. DOI: 10.1016/j.lfs.2025.124114
Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. Alexis Audibert, Xavier Mas‐Orea, ..., Chrystelle Bonnart, et al., PLOS Pathogens 2025. DOI: 10.1371/journal.ppat.1013106
Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the *British Journal of Pharmacology* in 2024. Andreas Papapetropoulos, Evan E. Santo, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2025. DOI: 10.1111/bph.70083
Modeling Postoperative Pathologic Ileus in Mice: A Simplified and Translational Approach. Romain Gauthier, Julie Thevenin, ..., Nathalie Vergnolle, ..., Céline Deraison, Neurogastroenterology & Motility 2025. DOI: 10.1111/nmo.70157
IDDF2025-ABS-0229 Biopsychosocial determinants of chronic abdominal pain in IBD during remission: findings from a UK national cohort. Pavit Luthra, Ruqaya Idrees, ..., Nathalie Vergnolle, et al., Clinical Gastroenterology 2025. DOI: 10.1136/gutjnl-2025-iddf.239
Stabilization of G-Quadruplexes Modulates the Expression of DNA Damage and Unfolded Protein Response Genes in Canine Lymphoma/Leukemia Cells. Beatriz Hernández‐Suárez, David A. Gillespie, et al., International Journal of Molecular Sciences 2025. DOI: 10.3390/ijms26209928
Evaluation of the prebiotic potential of polyphenol-rich plant extracts in a mouse model of colitis. Damien Guillemet, Perrine Rousset, ..., Anissa Edir, ..., Laura Guiraud, Nathalie Vergnolle, Jean‐Paul Motta, Microbiota and Host 2025. DOI: 10.1530/mah-25-0007
Human fallopian tube organoids provide a favourable environment for sperm motility. Nicolas Gatimel, G. Perez, ..., Céline Deraison, Jean‐Paul Motta, ..., Nathalie Vergnolle, Human Reproduction 2025. DOI: 10.1093/humrep/deae258
Proteases in intestinal health and disease. Céline Deraison, Nathalie Vergnolle, Nature Reviews Gastroenterology & Hepatology 2025. DOI: 10.1038/s41575-025-01129-w
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: a year in review. Stavros Topouzis, Andreas Papapetropoulos, ..., Nathalie Vergnolle, et al., Authorea Inc. 2025. DOI: 10.22541/au.173621928.86704200/v1
A6 INVESTIGATING THE RELATIONSHIP BETWEEN MUCOSAL INFLAMMATION AND PROTEOLYTIC ACTIVITY IN CROHN’S DISEASE. J Szeto, Gaston Rueda, ..., Céline Deraison, Nathalie Vergnolle, et al., Journal of the Canadian Association of Gastroenterology 2025. DOI: 10.1093/jcag/gwae059.006
Epithelial thrombin-PAR1 signaling and Nippostrongylus brasiliensis infection drive small intestinal villus vascularization. Maximilian Mimmler, E. Aubel, ..., Nathalie Vergnolle, et al., Hämostaseologie 2025. DOI: 10.1055/s-0044-1801583
O60 Chronic abdominal pain in ibd during remission: psychological and physiological factors driving pain severity and interference. Pavit Luthra, Ruqaya Idrees, ..., Nathalie Vergnolle, et al., Oral Presentations 2025. DOI: 10.1136/gutjnl-2025-bsg.59
P261 Chronic abdominal pain in IBD: a comparison of health-related quality of life in active disease and remission. Pavit Luthra, Ruqaya Idrees, ..., Nathalie Vergnolle, et al., Posters 2025. DOI: 10.1136/gutjnl-2025-bsg.395
P34 Insights into chronic abdominal pain in IBD during remission: key psychological and physiological predictors from a UK cross-sectional study. Pavit Luthra, Ruqaya Idrees, ..., Nathalie Vergnolle, et al., Posters 2025. DOI: 10.1136/gutjnl-2025-bsg.171
Mo1262: DEVELOPING A CLINICAL PHENOTYPE FOR CHRONIC ABDOMINAL PAIN IN INFLAMMATORY BOWEL DISEASE: RESULTS FROM A LARGE UNITED KINGDOM CROSS SECTIONAL STUDY. Pavit Luthra, Ruqaya Idrees, ..., Nathalie Vergnolle, et al., Gastroenterology 2025. DOI: 10.1016/s0016-5085(25)03375-x
Sa1782: ROLE OF EPITHELIAL THROMBIN ON GUT DYSBIOSIS IN CROHN’S DISEASE. Guillaume Le Cosquer, Mélissa Pannier, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gastroenterology 2025. DOI: 10.1016/s0016-5085(25)02150-x
Next-generation enteric neuroscience — fostering the future of the field. Anoohya N. Muppirala, Mitchell Ringuet, ..., Nathalie Vergnolle, Nature Reviews Gastroenterology & Hepatology 2025. DOI: 10.1038/s41575-025-01102-7
Ebus Guided Transbronchial Mediastinal Cryobiopsy: Brazil's First Cohort. Marcos de Carvalho Bethlem, Blas Peixoto, Jean‐Paul Motta, et al., American Journal of Respiratory and Critical Care Medicine 2025. DOI: 10.1164/ajrccm.2025.211.abstracts.a4091
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism. Leïla Dumas, Sauyeun Shin, ..., Beatriz Hernández‐Suárez, et al., Nature Communications 2025. DOI: 10.1038/s41467-025-58118-5
Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission. Sofia Faggin, Silvia Cerantola, et al., British Journal of Pharmacology 2025. DOI: 10.1111/bph.17439
Sex-dependent alteration of the enteric neuromuscular function after antibiotic-induced dysbiosis in juvenile mice and effect of Lactocaseibacillus rhamnosus GG. Annalisa Bosi, Davide Banfi, ..., Sofia Faggin, et al., Biomedicine & Pharmacotherapy 2025. DOI: 10.1016/j.biopha.2025.118263
The Small Intestinal Microbiota and the Gut–Brain Axis in Parkinson’s Disease: A Narrative Review. Gloria Carrossa, Valentina Misenti, Sofia Faggin, et al., Biomedicines 2025. DOI: 10.3390/biomedicines13071769
Small Intestine Neuromuscular Dysfunctions and Neurogliopathy in a Mouse Model of High-Fat Diet-Induced Obesity: Involvement of Toll-Like Receptor 4. Sofia Faggin, Silvia Cerantola, et al., International Journal of Molecular Sciences 2025. DOI: 10.3390/ijms262110710
Gut-Brain Axis and Parkinson's Disease: The Role of Small Intestinal Microbiota from Symptom Onset to Therapeutic Perspectives. Gloria Carrossa, Valentina Misenti, Sofia Faggin, et al., 2025. DOI: 10.20944/preprints202506.0962.v1
Toll-like receptor 4 deficiency mitigates acute DNBS-induced enteric neurogliopathy via modulation of excitatory and 5-HTergic pathways. Sofia Faggin, Silvia Cerantola, et al., Authorea Inc. 2025. DOI: 10.22541/au.175050561.11108548/v1
Small Intestine Neuromuscular Dysfunctions and Neurogliopathy in a Mouse Model of High-Fat Diet-Induced Obesity: Involvement of Toll-Like Receptor 4. Sofia Faggin, Silvia Cerantola, et al., 2025. DOI: 10.20944/preprints202506.2222.v1
Immunohistochemical Localization and Anatomical Distribution of Enteric Glia Cells in Enteric Nervous System. Sofia Faggin, Valentina Caputi, et al., Methods in Molecular Biology 2025. DOI: 10.1007/978-1-0716-4795-0_2
Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review. Andreas Papapetropoulos, Stavros Topouzis, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.16337
Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome. Maria Raffaella Barbaro, Cesare Cremon, ..., Nathalie Vergnolle, et al., Gastroenterology 2024. DOI: 10.1053/j.gastro.2024.07.004
Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2. L Rondeau, B Barbosa da Luz, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Gut Microbes 2024. DOI: 10.1080/19490976.2024.2387857
Intestinal organoids to model Salmonella infection and its impact on progenitors. Yan Jin, Claire Racaud‐Sultan, ..., Anissa Edir, ..., Nathalie Vergnolle, Agnès Wiedemann, Scientific Reports 2024. DOI: 10.1038/s41598-024-65485-4
Trends in horizontal gene transfer research in Salmonella antimicrobial resistance: a bibliometric analysis. Yan Jin, Benoît Doublet, Agnès Wiedemann, Frontiers in Microbiology 2024. DOI: 10.3389/fmicb.2024.1439664
Gut microb-aging and its relevance to frailty aging. Guillaume Le Cosquer, Nathalie Vergnolle, Jean‐Paul Motta, Microbes and Infection 2024. DOI: 10.1016/j.micinf.2024.105309
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis. Nolwenn Laborde, Alexandre Barusseaud, ..., Nathalie Vergnolle, ..., Frédérick Barreau, Claire Racaud‐Sultan, Emmanuel Mas, The Journal of Pathology 2024. DOI: 10.1002/path.6366
The *Salmonella* virulence protein PagN contributes to the advent of a hyper-replicating cytosolic bacterial population. Sébastien Holbert, Émilie Barilleau, ..., Agnès Wiedemann, Virulence 2024. DOI: 10.1080/21505594.2024.2357670
Mapping the scientific output of organoids for animal and human modeling infectious diseases: a bibliometric assessment. Yan Jin, Jean Monlong, ..., Agnès Wiedemann, Veterinary Research 2024. DOI: 10.1186/s13567-024-01333-7
Organoids, organs-on-chips, complex in vitro model: Definitions, applications, validation, ethics. Guillaume Mottet, Alexandre Grassart, ..., Nathalie Vergnolle, et al., Therapies 2024. DOI: 10.1016/j.therap.2024.12.002
Chymotrypsin activity signals to intestinal epithelium by protease‐activated receptor‐dependent mechanisms. Simon Guignard, Mahmoud Saifeddine, ..., Laura Guiraud, ..., Anissa Edir, ..., Nathalie Vergnolle, ..., Céline Deraison, Chrystelle Bonnart, British Journal of Pharmacology 2024. DOI: 10.1111/bph.16341
The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. Giulia Trimaglio, Tamara Sneperger, ..., Nathalie Vergnolle, et al., Scientific Reports 2024. DOI: 10.1038/s41598-024-57941-y
TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Michelle Meng, Luke W Paine, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.17408
Human tetraspanin CD81 facilitates invasion of *Salmonella enterica* into human epithelial cells. Kris Gerard Alvarez, Lisa Goral, ..., Agnès Wiedemann, et al., Virulence 2024. DOI: 10.1080/21505594.2024.2399792
Thrombin stories in the gut. Nathalie Vergnolle, Biochimie 2024. DOI: 10.1016/j.biochi.2024.03.007
Natural product pharmacology: the British Journal of Pharmacology perspective. Xin Wang, Angelo A. Izzo, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.17300
Intestinal organoids to model Salmonella infection and its impact on progenitors. Yan Jin, Claire Racaud‐Sultan, ..., Anissa Edir, ..., Nathalie Vergnolle, Agnès Wiedemann, Research Square 2024. DOI: 10.21203/rs.3.rs-3834882/v1
O-096 Human fallopian tube organoids provide a favorable environment for sperm motility. Nicolas Gatimel, E Bruno, ..., Céline Deraison, ..., Nathalie Vergnolle, Human Reproduction 2024. DOI: 10.1093/humrep/deae108.102
*Toxoplasma gondii* chronic infection decreases visceral nociception through peripheral opioid receptor signaling. Alexis Audibert, Xavier Mas‐Orea, ..., Chrystelle Bonnart, et al., bioRxiv 2024. DOI: 10.1101/2024.09.13.612908
TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Michelle Meng, Luke W Paine, ..., Nathalie Vergnolle, et al., bioRxiv 2024. DOI: 10.1101/2024.04.12.589184
Pathogenicity of Commensal Gut Biofilm In Prefrail Aging. Guillaume Le Cosquer, Melissa Pannier, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, et al., bioRxiv 2024. DOI: 10.1101/2024.06.04.596782
Long-term effects of xenotransplantation of human enteric glia in immunocompetent rats with brain injury. Nina Colitti, Edwige Rice, ..., Nathalie Vergnolle, et al., bioRxiv 2024. DOI: 10.1101/2024.11.15.623633
Bispecific nanobody® as new pharmacological drug for the selective inhibition of Trypsin-3. Melissa DAVID, Anaïs Faihy, ..., Anissa Edir, ..., Nathalie Vergnolle, ..., Céline Deraison, Authorea Inc. 2024. DOI: 10.22541/au.173322563.37284703/v1
The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling. Ugo Sardo, Prunelle Perrier, ..., Jean Personnaz, Thanina Medjbeur, Aurore Desquesnes, Lisa Cannizzo, ..., Julie Thevenin, ..., Léon Kautz, Blood 2024. DOI: 10.1182/blood.2023022724
Mapping gut feelings and immune control. Nathalie Vergnolle, Science 2024. DOI: 10.1126/science.adq9533
Small intestinal villus vascularization is driven via an epithelial-to-endothelial PAR1 signaling axis. Maximilian Mimmler, Olga Dremova, ..., Nathalie Vergnolle, Jean‐Paul Motta, et al., Hämostaseologie 2024. DOI: 10.1055/s-0044-1779238
BOC.04.4: THE GUT VASCULAR BARRIER IS IMPAIRED IN IRRITABLE BOWEL SYNDROME: IMPLICATIONS FOR SYMPTOM DEVELOPMENT. Maria Raffaella Barbaro, Cesare Cremon, ..., Nathalie Vergnolle, et al., Digestive and Liver Disease 2024. DOI: 10.1016/s1590-8658(24)00391-8
Su1629 CHARACTERIZATION OF THE GUT VASCULAR BARRIER IN IRRITABLE BOWEL SYNDROME. Maria Raffaella Barbaro, Cesare Cremon, ..., Nathalie Vergnolle, et al., Gastroenterology 2024. DOI: 10.1016/s0016-5085(24)02257-1
Organoïdes, organes sur puce, complex in vitro model : définitions, applications, validation, éthique. Guillaume Mottet, Alexandre Grassart, ..., Nathalie Vergnolle, et al., Therapies 2024. DOI: 10.1016/j.therap.2024.12.003
Predictive Capacity of the Integrated Care for Older People Screening Tool for Intrinsic Capacity Impairments: Results From the INSPIRE-T Cohort. Kelly Virecoulon Giudici, Philipe de Souto Barreto, ..., Jean‐Paul Motta, et al., The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 2024. DOI: 10.1093/gerona/glae112
RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism. Leïla Dumas, Sauyeun Shin, ..., Beatriz Hernández‐Suárez, et al., bioRxiv 2024. DOI: 10.1101/2024.01.29.577192
Safety of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease. Angela Tietto, Sofia Faggin, et al., Expert Opinion on Drug Metabolism & Toxicology 2024. DOI: 10.1080/17425255.2024.2397433
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Liwen Deng, Flavia G. Costa, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Cell 2023. DOI: 10.1016/j.cell.2023.10.019
Differential Salmonella Typhimurium intracellular replication and host cell responses in caecal and ileal organoids derived from chicken. Sonia Lacroix‐Lamandé, Ophélie Bernardi, ..., Agnès Wiedemann, Veterinary Research 2023. DOI: 10.1186/s13567-023-01189-3
*O*-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases. Aurore Labourel, Jean‐Luc Parrou, Céline Deraison, et al., Essays in Biochemistry 2023. DOI: 10.1042/ebc20220153
Postoperative ileus: A pharmacological perspective. Étienne Buscail, Céline Deraison, British Journal of Pharmacology 2022. DOI: 10.1111/bph.15800
Cross-Talk Between the Intestinal Epithelium and Salmonella Typhimurium. Sandrine Ménard, Sonia Lacroix‐Lamandé, ..., Agnès Wiedemann, Frontiers in Microbiology 2022. DOI: 10.3389/fmicb.2022.906238
Identification of bacterial lipopeptides as key players in IBS. Camille Petitfils, Sarah Maurel, ..., Frédéric Auvray, ..., Jean‐Paul Motta, ..., Éric Oswald, et al., Gut 2022. DOI: 10.1136/gutjnl-2022-328084
Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy. André G. Buret, Thibault Allain, Jean‐Paul Motta, et al., Antioxidants & Redox Signaling 2021. DOI: 10.1089/ars.2021.0004
Intestinal organoids in farm animals. Martín Beaumont, Fany Blanc, ..., Agnès Wiedemann, Veterinary Research 2021. DOI: 10.1186/s13567-021-00909-x
A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917. Jean‐Philippe Nougayrède, Camille V. Chagneau, Jean‐Paul Motta, ..., Frédéric Taïeb, ..., Éric Oswald, mSphere 2021. DOI: 10.1128/msphere.00624-21
Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn’s Disease: Rationale, Clinical Results and Perspectives. Étienne Buscail, Guillaume Le Cosquer, ..., Céline Deraison, Nathalie Vergnolle, et al., International Journal of Molecular Sciences 2021. DOI: 10.3390/ijms22189967
Gastrointestinal biofilms in health and disease. Jean‐Paul Motta, John L. Wallace, ..., Céline Deraison, Nathalie Vergnolle, Nature Reviews Gastroenterology & Hepatology 2021. DOI: 10.1038/s41575-020-00397-y
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients. Emilie d'Aldebert, Muriel Quaranta, ..., Claire Racaud‐Sultan, Emmanuel Mas, Céline Deraison, Nathalie Vergnolle, Frontiers in Cell and Developmental Biology 2020. DOI: 10.3389/fcell.2020.00363
Revisiting the Hallmarks of Aging to Identify Markers of Biological Age. Florent Guerville, Philipe de Souto Barreto, ..., Nathalie Vergnolle, et al., The Journal of Prevention of Alzheimer's Disease 2020. DOI: 10.14283/jpad.2019.50
Characterization and Validation of a Chronic Model of Cyclophosphamide-Induced Interstitial Cystitis/Bladder Pain Syndrome in Rats. Céline Augé, X. Gamé, Nathalie Vergnolle, et al., Frontiers in Pharmacology 2020. DOI: 10.3389/fphar.2020.01305
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Alberto Caminero, Justin L. McCarville, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Nature Communications 2019. DOI: 10.1038/s41467-019-09037-9
Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner. Marion Rincel, P. Aubert, ..., Nathalie Vergnolle, et al., Brain, Behavior, and Immunity 2019. DOI: 10.1016/j.bbi.2019.03.006
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation. Nadine Serhan, Lilian Basso, ..., Chrystelle Bonnart, et al., Nature Immunology 2019. DOI: 10.1038/s41590-019-0493-z
Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?. André G. Buret, Jean‐Paul Motta, et al., Journal of Biomedical Science 2019. DOI: 10.1186/s12929-018-0495-4
Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function. Nathalie Vergnolle, Carla Cirillo, Physiology 2018. DOI: 10.1152/physiol.00009.2018
Protectin D1~n-3 DPA~ and resolvin D5~n-3 DPA~ are effectors of intestinal protection. Thomas Gobbetti, Jesmond Dalli, ..., Nathalie Vergnolle, Céline Deraison, et al., Proceedings of the National Academy of Sciences 2017. DOI: 10.1073/pnas.1617290114
Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Claire Rolland-Fourcade, Alexandre Denadai‐Souza, ..., Jean‐Paul Motta, ..., Céline Deraison, Nathalie Vergnolle, Gut 2017. DOI: 10.1136/gutjnl-2016-312094
Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms. Jennifer Beatty, Sarah Akierman, Jean‐Paul Motta, et al., International Journal for Parasitology 2017. DOI: 10.1016/j.ijpara.2016.11.010
Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface. John L. Wallace, Jean‐Paul Motta, et al., American Journal of Physiology-Gastrointestinal and Liver Physiology 2017. DOI: 10.1152/ajpgi.00249.2017
Interactions of*Giardia sp.*with the intestinal barrier: Epithelium, mucus, and microbiota. Thibault Allain, Christina Amat, Jean‐Paul Motta, et al., Tissue Barriers 2017. DOI: 10.1080/21688370.2016.1274354
Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. Anna Mańko, Jean‐Paul Motta, et al., PLOS ONE 2017. DOI: 10.1371/journal.pone.0178647
Cysteine Protease–Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection. Christina Amat, Jean‐Paul Motta, et al., The American Journal of Pathology 2017. DOI: 10.1016/j.ajpath.2017.07.009
The Intestinal Microenvironment and Functional Gastrointestinal Disorders. Giovanni Barbara, Christine Feinle‐Bisset, ..., Nathalie Vergnolle, et al., Gastroenterology 2016. DOI: 10.1053/j.gastro.2016.02.028
Protease inhibition as new therapeutic strategy for GI diseases. Nathalie Vergnolle, Gut 2016. DOI: 10.1136/gutjnl-2015-309147
*Giardia duodenalis*induces paracellular bacterial translocation and causes postinfectious visceral hypersensitivity. Marie C. M. Halliez, Jean‐Paul Motta, et al., American Journal of Physiology-Gastrointestinal and Liver Physiology 2016. DOI: 10.1152/ajpgi.00144.2015
