Pathogenesis and commensalism of enterobacteria
Team 2
Keywords: Bacterial Commensalism and Pathogenesis, Intestinal microbiota
The “Pathogenesis and Commensalism of Enterobacteria” team, led by Eric Oswald, employs a multidisciplinary approach (microbiology, molecular and cellular biology, immunology, metagenomics, integrative physiology, and animal models) to investigate the boundary between bacterial commensalism and pathogenesis and their role in modulating the host cell cycle, genomic integrity, physiology, and metabolism. To achieve these goals, new scientific and technological insights have been gained in various aspects of bacterial infection, intestinal colonization, and ecology.
The team focuses on multiple pathovars of Escherichia coli, including enteropathogenic, hemorrhagic, and extraintestinal pathogenic E. coli (EPEC, EHEC, and ExPEC), as well as commensal and probiotic E. coli and the intestinal microbiota. Their work also explores dysbiosis and its impact on infection, metabolic diseases, and carcinogenesis.
Several research axes are being developed:
- Toxins and cancers
- From commensalism to pathogenicity
- Pathogenic bacteria and antibiotic resistance
- Dysbiosis involving Escherichia coli and metabolic diseases
Membres
Toxins and cancer
From commensalism to pathogenicity
Pathogenic bacteria and antibiotic resistance
Publications
Article type:
Comment un mécanisme de résistance aux antibiotiques favorise la virulence bactérienne. Audrey Goman, Lola Manenc, ..., Priscilla Branchu, et al., médecine/sciences 2026. DOI: 10.1051/medsci/2025252
Is *Klebsiella pneumoniae* -associated bovine mastitis an emerging public health issue? A One Health perspective. Delphine Payros, Frédéric Auvray, et al., ASM Animal Microbiology 2026. DOI: 10.1128/asmam.00023-25
NLRP3 inflammasome partially mediates genotoxic E. coli infection in lean but not in genetically obese mice. Pauline Floch, Cécile Goursat, ..., Priscilla Branchu, et al., iScience 2026. DOI: 10.1016/j.isci.2026.116674
Comment un mécanisme de résistance aux antibiotiques favorise la virulence bactérienne. Audrey Goman, Lola Manenc, ..., Priscilla Branchu, et al., https://doi.org/10.1051/medsci/2025252 2026. DOI: 10.1051/medsci/2025252/pdf
Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment. Nathan Day, Baptiste Pradel, ..., Julien Vaubourgeix, et al., Nature Communications 2026. DOI: 10.1038/s41467-026-75915-8
Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges. Asja Garling, Frédéric Auvray, ..., Éric Oswald, Priscilla Branchu, Journal of Extracellular Vesicles 2025. DOI: 10.1002/jev2.70150
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals. Nicolas Jousserand, Frédéric Auvray, ..., Éric Oswald, Veterinary Research 2025. DOI: 10.1186/s13567-025-01493-0
Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria. Audrey Goman, Bérengère Ize, ..., Frédéric Taïeb, ..., Laure David, ..., Priscilla Branchu, Éric Oswald, Journal of Extracellular Vesicles 2025. DOI: 10.1002/jev2.70032
Development of intimin-enriched outer membrane vesicles (OMVs) as a vaccine to control intestinal carriage of Enterohemorrhagic Escherichia coli. Asja Garling, Cécile Goursat, ..., Jean‐Philippe Nougayrède, Éric Oswald, Frédéric Auvray, Priscilla Branchu, Vaccine 2025. DOI: 10.1016/j.vaccine.2025.126899
A Non-genotoxic Variant of Escherichia coli Nissle 1917 EcN 2.0 Overexpressing Microcins Reduces Intestinal Carriage of ST131 ESBL-Producing Escherichia coli. Nicolas Jousserand, Benjamin Massiera, ..., Éric Oswald, et al., Probiotics and Antimicrobial Proteins 2025. DOI: 10.1007/s12602-025-10777-y
Correction: Functionality integration in stereolithography 3D printed microfluidics using a “print-pause-print” strategy. Matthieu Sagot, Timothée Derkenne, ..., Jean‐Philippe Nougayrède, et al., Lab on a Chip 2025. DOI: 10.1039/d5lc90036k
Outer Membrane Vesicles from bacteria expressing the HlyF/CprA family of enzymes are more efficient at delivering their cargo into host cells. Frédéric Taïeb, Laure David, ..., Éric Oswald, bioRxiv 2025. DOI: 10.1101/2025.03.27.645671
Opinion and report of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the assessment of the impact of fox population dynamics on public health. Emmanuelle Gilot‐Fromont, Isabelle Villena, ..., Frédéric Auvray, et al., Food Risk Assess Europe 2025. DOI: 10.2903/fr.efsa.2025.fr-0062
Bacterial Hsp90 promotes virulence factor production through maintenance of NRPS megaenzymes. Alison Fratacci, Amine Ali Chaouche, ..., Jean‐Philippe Nougayrède, Éric Oswald, et al., bioRxiv 2025. DOI: 10.1101/2025.07.01.662645
Studying *Pseudomonas aeruginosa* pathogenesis: the need for more than just the PAO1 strain. Laure David, Audrey Goman, ..., Frédéric Taïeb, Priscilla Branchu, Éric Oswald, Microbiology Spectrum 2025. DOI: 10.1128/spectrum.00665-25
Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes. Andrea Majstorović, Hélène Botella, ..., Julien Vaubourgeix, bioRxiv 2025. DOI: 10.1101/2025.10.10.681568
Emergence and genetic heterogeneity of STEC O113:H4: insights from whole-genome sequences of isolates across human and non-human sources. Florence Crombé, Frédéric Auvray, et al., International Journal of Medical Microbiology 2025. DOI: 10.1016/j.ijmm.2025.151688
Residual antimicrobials in food can select for antimicrobial resistance. Elissa Khamisse, Xavier Bertrand, ..., Éric Oswald, The Lancet Microbe 2025. DOI: 10.1016/j.lanmic.2025.101302
Kinetics of molecular patterns captured by mannose-binding lectin in septic shock correlate with clinical outcome: a monocentric prospective observational study. A. Bicart-See, Fanny Vardon‐Bounes, ..., Éric Oswald, Intensive Care Medicine Experimental 2025. DOI: 10.1186/s40635-025-00832-x
Humans as a potential reservoir for the emerging ST301 Shiga toxin-producing Escherichia coli clones of serotype O80:H2?. Frédéric Auvray, Federica Gigliucci, ..., Éric Oswald, Clinical Microbiology and Infection 2025. DOI: 10.1016/j.cmi.2025.05.018
Bacterial nanoparticles as a potent and safe alternative to BCG for bladder cancer immunotherapy. Marine Colson, Arthur Aubry, ..., Éric Oswald, Laure David, Cancer Gene Therapy 2025. DOI: 10.1038/s41417-025-00984-8
Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on defining pathogenic strains of Shiga toxin‐producing Escherichia coli. Philippe Fravalo, Frédéric Auvray, et al., Food Risk Assess Europe 2025. DOI: 10.2903/fr.efsa.2025.fr-0065
Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks associated with the consumption of nitrites and nitrates. Marie‐Louise Scippo, Pierre‐Marie Badot, ..., Frédéric Auvray, et al., Food Risk Assess Europe 2025. DOI: 10.2903/fr.efsa.2025.fr-0059
Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the presence of Toxocara spp. parasites in wild boar meat. Philippe Fravalo, Frédéric Auvray, et al., Food Risk Assess Europe 2025. DOI: 10.2903/fr.efsa.2025.fr-0058
Development and Validation of an Escape Game for Food Safety Education: Gamifying the Management of a Food-Borne Health Alert. Pedro Henrique Didimo Imazaki, Carla Lewandowski, ..., Laure David, Journal of Veterinary Medical Education 2025. DOI: 10.3138/jvme-2024-0151
Functionality integration in stereolithography 3D printed microfluidics using a “print-pause-print” strategy. Matthieu Sagot, Timothée Derkenne, ..., Jean‐Philippe Nougayrède, et al., Lab on a Chip 2024. DOI: 10.1039/d4lc00147h
Intestinal Carriage of Two Distinct stx2f-Carrying Escherichia coli Strains by a Child with Uncomplicated Diarrhea. Florence Crombé, Angela H. A. M. van Hoek, ..., Frédéric Auvray, et al., Pathogens 2024. DOI: 10.3390/pathogens13111002
Development of intimin-enriched outer membrane vesicles (OMVs) as a vaccine to control intestinal carriage of Enterohemorrhagic *Escherichia coli*. Asja Garling, Cécile Goursat, ..., Jean‐Philippe Nougayrède, Éric Oswald, Frédéric Auvray, Priscilla Branchu, bioRxiv 2024. DOI: 10.1101/2024.12.09.627534
The Positive Impact of Virulence Genes in Bacterial Pathogenicity and Colonization on the Large Bowel in Colorectal Cancer Patients. Mohammad Khalilolahi, Fatemeh Ashrafi, ..., Jean‐Philippe Nougayrède, et al., Iranian Journal of Blood and Cancer 2024. DOI: 10.61186/ijbc.16.3.63
Monkeypox Clade II en France en 2023 : une situation endémique ?. Mayda Rahi, Marie Gilbert, ..., Frédéric Taïeb, et al., Médecine et Maladies Infectieuses Formation 2024. DOI: 10.1016/j.mmifmc.2024.04.019
From ribosome to ribotoxins: understanding the toxicity of deoxynivalenol and Shiga toxin, two food borne toxins. Marion Garofalo, Delphine Payros, Frédéric Taïeb, ..., Jean‐Philippe Nougayrède, et al., Critical Reviews in Food Science and Nutrition 2023. DOI: 10.1080/10408398.2023.2271101
Outer membrane vesicles produced by pathogenic strains of *Escherichia coli* block autophagic flux and exacerbate inflammasome activation. Laure David, Frédéric Taïeb, ..., Éric Oswald, Autophagy 2022. DOI: 10.1080/15548627.2022.2054040
Identification of bacterial lipopeptides as key players in IBS. Camille Petitfils, Sarah Maurel, ..., Frédéric Auvray, ..., Jean‐Paul Motta, ..., Éric Oswald, et al., Gut 2022. DOI: 10.1136/gutjnl-2022-328084
The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer. Camille V. Chagneau, Delphine Payros, ..., Frédéric Auvray, Jean‐Philippe Nougayrède, Éric Oswald, Trends in Microbiology 2022. DOI: 10.1016/j.tim.2022.05.010
Role of milk and milk products in the spread of methicillin‐resistant *Staphylococcus aureus* in the dairy production chain. Yacine Titouche, Madjid Akkou, ..., Frédéric Auvray, et al., Journal of Food Science 2022. DOI: 10.1111/1750-3841.16259
A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917. Jean‐Philippe Nougayrède, Camille V. Chagneau, Jean‐Paul Motta, ..., Frédéric Taïeb, ..., Éric Oswald, mSphere 2021. DOI: 10.1128/msphere.00624-21
Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis. Julien Pujo, Camille Petitfils, ..., Frédérick Barreau, ..., Éric Oswald, et al., Gut 2020. DOI: 10.1136/gutjnl-2020-321173
Biology of antimicrobial resistance and approaches to combat it. Sarah Schrader, Julien Vaubourgeix, et al., Science Translational Medicine 2020. DOI: 10.1126/scitranslmed.aaz6992
Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. Clémence Massip, Priscilla Branchu, ..., Jean‐Philippe Nougayrède, Éric Oswald, PLOS Pathogens 2019. DOI: 10.1371/journal.ppat.1008029
SGI-4 in Monophasic Salmonella Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper. Priscilla Branchu, Oliver J. Charity, et al., Frontiers in Microbiology 2019. DOI: 10.3389/fmicb.2019.01118
Emergence of methicillin-resistant Staphylococcus aureus (MRSA) ST8 in raw milk and traditional dairy products in the Tizi Ouzou area of Algeria. Yacine Titouche, Ahcène Hakem, ..., Frédéric Auvray, Journal of Dairy Science 2019. DOI: 10.3168/jds.2018-16208
Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization. Peter T. McKenney, Jinyuan Yan, Julien Vaubourgeix, et al., Cell Host & Microbe 2019. DOI: 10.1016/j.chom.2019.03.008
The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. Nadège Bossuet‐Greif, Julien Vignard, Frédéric Taïeb, ..., Éric Oswald, Jean‐Philippe Nougayrède, mBio 2018. DOI: 10.1128/mbio.02393-17
Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants. Priscilla Branchu, Matt Bawn, et al., Infection and Immunity 2018. DOI: 10.1128/iai.00079-18
Targeting the Proteostasis Network for Mycobacterial Drug Discovery. Tania J. Lupoli, Julien Vaubourgeix, et al., ACS Infectious Diseases 2018. DOI: 10.1021/acsinfecdis.7b00231
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis. Sarah Tomkovich, Ye Yang, ..., Éric Oswald, et al., Cancer Research 2017. DOI: 10.1158/0008-5472.can-16-3472
Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Teresa Pérez, Julien Pujo, ..., Frédérick Barreau, ..., Éric Oswald, et al., Nature Communications 2017. DOI: 10.1038/s41467-017-01403-9
The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. Delphine Payros, Ulrich Dobrindt, ..., Éric Oswald, et al., mBio 2017. DOI: 10.1128/mbio.00007-17
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between *Mycobacterium smegmatis* and *Mycobacterium tuberculosis*. Hélène Botella, Guangli Yang, ..., Julien Vaubourgeix, mBio 2017. DOI: 10.1128/mbio.01183-17
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death. Laure Botella, Julien Vaubourgeix, et al., Nature Communications 2017. DOI: 10.1038/ncomms14731
Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Céline Besson‐Fournier, Aurélie Gineste, Chloé Latour, ..., Delphine Meynard, ..., Éric Oswald, Hélène Coppin, Marie‐Paule Roth, Blood 2016. DOI: 10.1182/blood-2016-10-748541
The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. Frédéric Taïeb, C. Petit, Jean‐Philippe Nougayrède, Éric Oswald, EcoSal Plus 2016. DOI: 10.1128/ecosalplus.esp-0008-2016
MATE transport of the E. coli-derived genotoxin colibactin. Jarrod J. Mousa, Ye Yang, ..., Éric Oswald, et al., Nature Microbiology 2016. DOI: 10.1038/nmicrobiol.2015.9
Early settlers: which*E. coli*strains do you not want at birth?. Thomas Sécher, Camille Bréhin, Éric Oswald, American Journal of Physiology-Gastrointestinal and Liver Physiology 2016. DOI: 10.1152/ajpgi.00091.2016
Microevolution of Monophasic *Salmonella* Typhimurium during Epidemic, United Kingdom, 2005–2010. Liljana Petrovska, Alison E. Mather, ..., Priscilla Branchu, et al., Emerging Infectious Diseases 2016. DOI: 10.3201/eid2204.150531
